ENDOG

Across TCGA pan-cancer cohorts, ENDOG mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ENDOG data layer compared with 24 for mass-spec protein.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher ENDOG mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ENDOG expression acts as an unfavorable survival marker, although some lineages such as CCRCC and UCEC show a favorable association.

CCRCC, UCEC, and LUAD are the cancer types where ENDOG mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.933	0.739	.001	22	view →
UCEC	OS	Tertile	II,III,IV	1.000	0.587	.048	12	view →
LUAD	OS	Quartile	All	0.373	0.982	.009	10	view →
PDAC	DFS	Quartile	All	0.590	0.347	.029	2	view →
GBM	OS	Tertile	All	0.955	0.750	.017	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ENDOG–CCRCC (OS)

Open the CCRCC breakdown →