EN1

Across TCGA patient cohorts, EN1 mutation is significantly associated with the RNA expression of many other genes, with 877 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EN1-associated genes across cancer lineages are RBMY2AP, RBMY1E, and RNU6-6P. Each is linked with EN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EN1-to-partner and partner-to-EN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBMY2AP grouped by EN1-low versus EN1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EN1→partner) and Y-score (partner→EN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RBMY2AP →	+0.069	+8.055	<.001	.007	3	2
BRCA	RBMY1E →	+0.079	+9.057	<.001	.003	3	2
UCEC	RNU6-6P →	+0.633	+2.075	<.001	.007	3	1
UCEC	MIR7702 →	+0.263	+4.475	<.001	.003	3	1
UCEC	FRG1HP →	+0.694	+3.732	<.001	<.001	3	1
UCEC	MIR6780B →	+0.287	+2.567	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 877 associations by consensus.

RBMY2AP by EN1 expression — BRCA

Explore this box plot interactively →