EMP3

Across TCGA patient cohorts, EMP3 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EMP3-associated genes across cancer lineages are EGFR_pY1068, ERK2, and Fibronectin. Each is linked with EMP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both EMP3-to-partner and partner-to-EMP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by EMP3-low versus EMP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EMP3→partner) and Y-score (partner→EMP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.310	-3.000	.032	.037	3	1
UCEC	ERK2 →	+0.279	+3.000	.012	.037	3	1
UCEC	Fibronectin →	-0.412	-2.990	.030	.036	3	1
UCEC	Bax →	+0.352	+2.817	.011	.036	2	1
UCEC	Chk2_pT68 →	-0.221	-3.000	.040	.037	2	1
UCEC	JNK2 →	+0.351	+3.000	.002	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

EGFR_pY1068 by EMP3 expression — UCEC

Explore this box plot interactively →