EMP3

Across TCGA pan-cancer cohorts, EMP3 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of EMP3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where EMP3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types EMP3 is over-expressed in tumor, although a few such as BLCA and LUSC show the opposite, repressed pattern.

KIRC, HNSC, and KIRP are the cancer types where EMP3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EMP3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.993	<.001	12	view →
HNSC	Female	IV	+1.848	<.001	11	view →
KIRP	Male	All	+1.415	<.001	9	view →
BLCA	Male	III,IV	−2.258	<.001	8	view →
LUSC	Female	All	−1.630	<.001	8	view →
LUAD	Male	All	−1.176	<.001	8	view →
THCA	Male	II,III,IV	+1.095	<.001	8	view →
UCEC	All	All	−2.122	<.001	6	view →
KICH	Female	All	−1.611	<.001	4	view →
COAD	Male	All	−0.864	.004	4	view →
BRCA	All	II,III,IV	−0.344	.011	4	view →
PRAD	All	All	−1.098	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

EMP3–KIRC

Open the KIRC breakdown →