EMP1

Across TCGA patient cohorts, EMP1 mutation is significantly associated with the RNA expression of many other genes, with 125 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EMP1-associated genes across cancer lineages are RNA5SP417, MIR516B1, and RN7SKP121. Each is linked with EMP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EMP1-to-partner and partner-to-EMP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP417 grouped by EMP1-low versus EMP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EMP1→partner) and Y-score (partner→EMP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP417 →	+0.658	+2.766	<.001	.007	3	2
BRCA	MIR516B1 →	+0.398	+8.055	<.001	.007	3	1
BRCA	RN7SKP121 →	+0.168	+8.055	<.001	.007	3	1
UCEC	MIR8082 →	+0.407	+2.976	.001	.004	3	1
UCEC	CICP28 →	+0.023	+2.766	.005	.007	3	1
UCEC	FGF21 →	+0.734	+3.983	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 125 associations by consensus.

RNA5SP417 by EMP1 expression — UCEC

Explore this box plot interactively →