EML4

Across TCGA patient cohorts, EML4 protein abundance is significantly associated with the RNA expression of many other genes, with 14,868 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible EML4-associated genes across cancer lineages are GALM, EVA1A, and HLA-DPB1. Each is linked with EML4 in more than 7 cancer types. Because this analysis shows association rather than direction, both EML4-to-partner and partner-to-EML4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EML4 versus GALM in HNSC, with a Pearson correlation of 0.29.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EML4→partner) and Y-score (partner→EML4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GALM →	+0.765	+0.251	.003	.001	3	8
LUAD	EVA1A →	+0.908	+0.273	<.001	<.001	3	5
GBM	HLA-DPB1 →	+0.884	+0.243	.005	.004	3	5
LUAD	EML4-AS1 →	+0.635	+0.289	<.001	<.001	3	5
OV	IL27RA →	+0.877	+0.242	.003	.001	3	4
OV	DTNB →	+0.569	+0.299	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,868 associations by consensus.

EML4 vs GALM — HNSC

Explore this scatter interactively →