EML2

Across TCGA cell cohorts, EML2 mutation is significantly associated with the RNA expression of many other genes, with 323 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EML2-associated genes across cancer lineages are LYG1, MEIOC, and C12orf60. Each is linked with EML2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EML2-to-partner and partner-to-EML2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LYG1 grouped by EML2-low versus EML2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EML2→partner) and Y-score (partner→EML2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LYG1 →	+0.871	+2.502	<.001	.005	3	2
LARGE_INTESTINE	MEIOC →	+0.414	+2.404	<.001	.009	3	2
LARGE_INTESTINE	C12orf60 →	+0.503	+2.588	.003	.004	3	2
BLOOD_Leukemia	C9 →	+0.856	+2.807	<.001	.008	3	1
BLOOD_Leukemia	PROX1 →	+0.570	+3.266	<.001	.008	3	1
BLOOD_Leukemia	VSX2 →	+0.035	+3.258	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 323 associations by consensus.

LYG1 by EML2 expression — LARGE_INTESTINE

Explore this box plot interactively →