EMG1

Across TCGA patient cohorts, EMG1 mutation is significantly associated with the RNA expression of many other genes, with 105 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EMG1-associated genes across cancer lineages are CLPB, DOLPP1, and KIR3DL1. Each is linked with EMG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EMG1-to-partner and partner-to-EMG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLPB grouped by EMG1-low versus EMG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EMG1→partner) and Y-score (partner→EMG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CLPB →	+0.694	+3.332	.001	.005	3	1
UCEC	DOLPP1 →	+0.743	+3.332	<.001	.005	3	1
UCEC	KIR3DL1 →	+0.242	+3.495	.002	.008	3	1
UCEC	LETM1 →	+0.567	+3.364	.002	.005	3	1
UCEC	ATPAF2 →	+0.546	+3.332	<.001	.005	3	1
UCEC	RPS6KB2 →	+0.485	+3.343	.008	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 105 associations by consensus.

CLPB by EMG1 expression — UCEC

Explore this box plot interactively →