EMCN

Across TCGA patient cohorts, EMCN mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EMCN-associated genes across cancer lineages are GSK-3_pS9, mTOR_pS2448, and Myosin-IIa_pS1943. Each is linked with EMCN in more than 1 cancer types. Because this analysis shows association rather than direction, both EMCN-to-partner and partner-to-EMCN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK-3_pS9 grouped by EMCN-low versus EMCN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EMCN→partner) and Y-score (partner→EMCN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK-3_pS9 →	-0.451	-2.459	.010	.019	3	1
UCEC	mTOR_pS2448 →	-0.132	-2.986	.042	.035	3	1
UCEC	Myosin-IIa_pS1943 →	+0.203	+2.128	.024	.010	3	1
UCEC	Notch1 →	+0.192	+2.807	.001	.003	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.470	-2.459	.016	.019	3	1
UCEC	PCNA →	+0.241	+2.459	.010	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

GSK-3_pS9 by EMCN expression — UCEC

Explore this box plot interactively →