EMC7

Across TCGA patient cohorts, EMC7 mutation is significantly associated with the RNA expression of many other genes, with 1,298 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EMC7-associated genes across cancer lineages are MIR4710, KRTAP25-1, and MIR1185-1. Each is linked with EMC7 in more than 1 cancer types. Because this analysis shows association rather than direction, both EMC7-to-partner and partner-to-EMC7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4710 grouped by EMC7-low versus EMC7-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EMC7→partner) and Y-score (partner→EMC7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIR4710 →	+0.713	+4.602	<.001	.008	3	2
BRCA	KRTAP25-1 →	+0.104	+8.055	<.001	.007	3	2
BLCA	MIR1185-1 →	+0.323	+7.640	<.001	.009	3	2
COAD	OR9Q2 →	+0.067	+5.721	<.001	.001	3	1
COAD	RNU6-1127P →	+0.476	+5.721	<.001	.001	3	1
COAD	RNU6-1068P →	+0.343	+4.602	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,298 associations by consensus.

MIR4710 by EMC7 expression — COAD

Explore this box plot interactively →