EMC7

Across TCGA pan-cancer cohorts, EMC7 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated EMC7 data layer compared with 1 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher EMC7 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated EMC7 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SARC show a favorable association.

HNSC, UVM, and KICH are the cancer types where EMC7 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.703	0.793	<.001	179	view →
UVM	DFS	Median	All	0.324	0.705	<.001	150	view →
KICH	OS	Median	II,III,IV	0.627	1.000	<.001	108	view →
BLCA	DFS	Quartile	III,IV	0.174	0.360	.008	94	view →
UCEC	OS	Tertile	II,III,IV	0.769	0.266	.006	50	view →
ACC	DFS	Tertile	All	0.248	0.696	.001	43	view →
UCS	OS	Quartile	II,III,IV	0.141	0.880	<.001	42	view →
SCLC	DFS	Tertile	II,III,IV	0.267	0.825	.006	31	view →
SARC	OS	Median	All	0.818	0.662	<.001	25	view →
READ	OS	Quartile	III,IV	0.701	0.967	.007	22	view →
THCA	DFS	Quartile	All	0.967	0.857	.003	21	view →
LUAD	OS	Tertile	II,III,IV	0.663	0.846	.014	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

EMC7–HNSC (OS)

Open the HNSC breakdown →