EMC7

Across TCGA patient cohorts, EMC7 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EMC7-associated genes across cancer lineages are Ku80, S6_pS235_S236, and SLC1A5. Each is linked with EMC7 in more than 1 cancer types. Because this analysis shows association rather than direction, both EMC7-to-partner and partner-to-EMC7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by EMC7-low versus EMC7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EMC7→partner) and Y-score (partner→EMC7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.280	+3.013	.023	.018	3	1
UCEC	S6_pS235_S236 →	+0.590	+3.000	.009	.036	3	1
UCEC	SLC1A5 →	-0.524	-3.000	.024	.035	3	1
UCEC	eIF4E →	+0.221	+3.321	.045	.010	2	1
UCEC	VHL →	-1.256	-3.000	<.001	.036	2	1
UCEC	S6_pS240_S244 →	+0.759	+3.321	<.001	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Ku80 by EMC7 expression — UCEC

Explore this box plot interactively →