EMC2

Across TCGA patient cohorts, EMC2 mutation is significantly associated with the RNA expression of many other genes, with 2,700 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EMC2-associated genes across cancer lineages are RNA5SP369, SRIP1, and KRTAP19-11P. Each is linked with EMC2 in more than 2 cancer types. Because this analysis shows association rather than direction, both EMC2-to-partner and partner-to-EMC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP369 grouped by EMC2-low versus EMC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EMC2→partner) and Y-score (partner→EMC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP369 →	+0.333	+2.193	.001	.005	3	3
LUSC	SRIP1 →	+0.170	+5.474	<.001	.005	3	2
BRCA	KRTAP19-11P →	+0.337	+7.731	<.001	.009	3	2
STAD	BPY2DP →	+0.331	+5.105	<.001	.008	3	2
UCEC	TCP11X3P →	+0.258	+1.895	<.001	.005	3	2
UCEC	RPS10-NUDT3 →	+0.321	+2.724	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,700 associations by consensus.

RNA5SP369 by EMC2 expression — UCEC

Explore this box plot interactively →