EMC2

Across TCGA pan-cancer cohorts, EMC2 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of EMC2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where EMC2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types EMC2 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, KIRC, and THCA are the cancer types where EMC2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EMC2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+0.967	<.001	10	view →
KIRC	Female	All	+0.527	<.001	10	view →
THCA	Male	III,IV	−0.494	<.001	10	view →
LIHC	Male	II,III,IV	+1.546	<.001	9	view →
BRCA	All	II,III,IV	+0.316	<.001	6	view →
STAD	All	II,III,IV	+0.435	.018	4	view →
COAD	Male	II,III,IV	+0.310	.014	4	view →
CHOL	All	All	+1.721	<.001	3	view →
ESCA	All	All	+0.405	.011	2	view →
BLCA	All	All	+0.282	.011	2	view →
LUSC	All	All	+0.191	.020	2	view →
KICH	Male	IV	+0.580	.004	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

EMC2–HNSC

Open the HNSC breakdown →