EMC2

Across TCGA patient cohorts, EMC2 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EMC2-associated genes across cancer lineages are EGFR_pY1068, FOXO3a_pS318_S321, and JNK_pT183_Y185. Each is linked with EMC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EMC2-to-partner and partner-to-EMC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by EMC2-low versus EMC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EMC2→partner) and Y-score (partner→EMC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.378	-3.000	.004	.036	3	1
UCEC	FOXO3a_pS318_S321 →	-0.189	-2.990	.003	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.227	-3.000	.010	.036	3	1
UCEC	Ku80 →	+0.297	+2.183	.016	.035	3	1
UCEC	Notch1 →	+0.274	+3.321	<.001	.010	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.697	-3.169	.003	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

EGFR_pY1068 by EMC2 expression — UCEC

Explore this box plot interactively →