EMC1

Across TCGA cell cohorts, EMC1 mutation is significantly associated with the RNA expression of many other genes, with 328 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EMC1-associated genes across cancer lineages are KRTAP1-3, GCAT, and DDHD1. Each is linked with EMC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EMC1-to-partner and partner-to-EMC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP1-3 grouped by EMC1-low versus EMC1-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EMC1→partner) and Y-score (partner→EMC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	KRTAP1-3 →	+0.038	+4.209	<.001	.006	3	1
LARGE_INTESTINE	GCAT →	+1.307	+3.212	.001	.006	3	1
LARGE_INTESTINE	DDHD1 →	+0.850	+3.212	.001	.006	3	1
LARGE_INTESTINE	PARD6A →	+0.903	+3.299	<.001	.004	3	1
LARGE_INTESTINE	FAM149A →	+1.491	+3.067	<.001	.009	3	1
LARGE_INTESTINE	COQ5 →	+0.571	+3.212	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 328 associations by consensus.

KRTAP1-3 by EMC1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →