ELP5

Across TCGA patient cohorts, ELP5 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ELP5-associated genes across cancer lineages are Myosin-IIa_pS1943, p62 Lck ligand, and PDK1_pS241. Each is linked with ELP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ELP5-to-partner and partner-to-ELP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Myosin-IIa_pS1943 grouped by ELP5-low versus ELP5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ELP5→partner) and Y-score (partner→ELP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Myosin-IIa_pS1943 →	+0.236	+2.183	.029	.035	3	1
UCEC	p62 Lck ligand →	+0.402	+2.817	.018	.036	3	1
UCEC	PDK1_pS241 →	+0.205	+2.833	.022	.034	3	1
UCEC	VHL →	-1.177	-3.169	<.001	.019	3	1
UCEC	Caspase-8 →	-0.267	-2.973	.043	.035	3	1
UCEC	Shc_pY317 →	-0.219	-3.169	.005	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Myosin-IIa_pS1943 by ELP5 expression — UCEC

Explore this box plot interactively →