ELP5

Across TCGA pan-cancer cohorts, ELP5 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated ELP5 data layer compared with 6 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher ELP5 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ELP5 expression acts as an unfavorable survival marker, although some lineages such as BRCA and PAAD show a favorable association.

ACC, KICH, and BRCA are the cancer types where ELP5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.239	0.668	<.001	96	view →
KICH	OS	Tertile	All	0.567	1.000	.001	94	view →
BRCA	OS	Tertile	III,IV	0.903	0.739	.003	54	view →
LIHC	OS	Median	III,IV	0.328	0.678	<.001	50	view →
MESO	OS	Tertile	II,III,IV	0.368	0.712	<.001	43	view →
KIRC	DFS	Quartile	III,IV	0.615	0.838	.005	31	view →
LUAD	DFS	Quartile	II,III,IV	0.312	0.742	.001	30	view →
CHOL	DFS	Tertile	All	0.187	0.687	<.001	28	view →
SARC	OS	Tertile	All	0.393	0.649	<.001	27	view →
PAAD	OS	Quartile	All	0.688	0.390	.004	26	view →
SKCM	DFS	Median	IV	0.559	0.188	.014	10	view →
UVM	OS	Median	III,IV	0.224	0.836	<.001	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

ELP5–ACC (DFS)

Open the ACC breakdown →