ELP4

Across TCGA patient cohorts, ELP4 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ELP4-associated genes across cancer lineages are Src_pY416, YB-1, and c-Jun_pS73. Each is linked with ELP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ELP4-to-partner and partner-to-ELP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Src_pY416 grouped by ELP4-low versus ELP4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ELP4→partner) and Y-score (partner→ELP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Src_pY416 →	-0.256	-3.308	.042	.010	3	1
UCEC	YB-1 →	+0.180	+3.000	.030	.036	3	1
UCEC	c-Jun_pS73 →	-0.184	-3.160	.027	.019	3	1
UCEC	JNK2 →	+0.276	+3.321	.007	.010	2	1
UCEC	PDK1_pS241 →	+0.238	+2.183	.008	.035	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Src_pY416 by ELP4 expression — UCEC

Explore this box plot interactively →