ELP2

Across TCGA cell cohorts, ELP2 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ELP2-associated genes across cancer lineages are PRAMEF10, PRAMEF17, and PRAMEF15. Each is linked with ELP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ELP2-to-partner and partner-to-ELP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF10 grouped by ELP2-low versus ELP2-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ELP2→partner) and Y-score (partner→ELP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PRAMEF10 →	+0.885	+4.643	<.001	.004	3	1
LUNG_SCLC	PRAMEF17 →	+0.010	+4.643	<.001	.004	3	1
LUNG_SCLC	PRAMEF15 →	+0.478	+4.817	<.001	.001	3	1
SKIN	KRTAP5-4 →	+0.084	+5.562	<.001	<.001	3	1
BLOOD_Lymphoma	AVP →	+0.038	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	OR51T1 →	+0.018	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

PRAMEF10 by ELP2 expression — LUNG_SCLC

Explore this box plot interactively →