ELOA

Across TCGA patient cohorts, ELOA mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ELOA-associated genes across cancer lineages are PCNA, 4E-BP1, and Cyclin-E2. Each is linked with ELOA in more than 1 cancer types. Because this analysis shows association rather than direction, both ELOA-to-partner and partner-to-ELOA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by ELOA-low versus ELOA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ELOA→partner) and Y-score (partner→ELOA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.255	+3.584	.001	.002	3	2
UCEC	4E-BP1 →	+0.266	+2.029	.006	.017	3	2
UCEC	Cyclin-E2 →	+0.165	+2.817	.006	.001	3	2
UCEC	eEF2 →	+0.363	+2.700	.004	.005	3	1
UCEC	EGFR →	-0.175	-2.584	.002	.010	3	1
UCEC	A-Raf_pS299 →	-0.135	-3.700	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

PCNA by ELOA expression — UCEC

Explore this box plot interactively →