ELOA

Across TCGA pan-cancer cohorts, ELOA RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ELOA’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where ELOA RNA is repressed in tumor relative to normal tissue. In most cancer types ELOA is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, BLCA, and THCA are the cancer types where ELOA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ELOA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−1.253	<.001	10	view →
BLCA	Male	III,IV	+0.820	<.001	9	view →
THCA	Male	III,IV	−0.692	<.001	9	view →
LUAD	All	II,III,IV	−0.450	<.001	8	view →
HNSC	Male	All	+0.430	<.001	8	view →
KIRP	Male	All	−0.491	<.001	2	view →
PRAD	All	All	+0.277	.002	2	view →
KIRC	Male	II,III,IV	−0.243	.024	2	view →
LIHC	All	All	+0.224	.018	2	view →
LUSC	All	All	−0.195	.012	2	view →
STAD	Male	II,III,IV	+0.458	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ELOA–KICH

Open the KICH breakdown →