ELN-AS1

Across TCGA pan-cancer cohorts, ELN-AS1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ELN-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ELN-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types ELN-AS1 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, KIRC, and LUSC are the cancer types where ELN-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ELN-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	IV	−2.412	<.001	11	view →
KIRC	Male	II,III,IV	−0.788	<.001	9	view →
LUSC	Female	II,III,IV	−2.924	<.001	8	view →
KICH	Female	II,III,IV	−2.117	<.001	8	view →
BLCA	Male	III,IV	−1.387	<.001	8	view →
LUAD	Female	All	−0.986	<.001	7	view →
UCEC	All	All	−1.933	<.001	6	view →
STAD	Female	III,IV	−1.240	<.001	5	view →
KIRP	Female	All	+0.919	.011	4	view →
BRCA	Female	II,III,IV	−0.408	.013	4	view →
CHOL	All	All	+1.508	.002	2	view →
PAAD	All	All	+0.772	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ELN-AS1–THCA

Open the THCA breakdown →