ELL

Across TCGA cell cohorts, ELL mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ELL-associated genes across cancer lineages are TTLL8, TBC1D21, and OR10W1. Each is linked with ELL in more than 1 cancer types. Because this analysis shows association rather than direction, both ELL-to-partner and partner-to-ELL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TTLL8 grouped by ELL-low versus ELL-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ELL→partner) and Y-score (partner→ELL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TTLL8 →	+0.002	+3.700	<.001	.009	3	1
LARGE_INTESTINE	TBC1D21 →	+0.008	+3.700	<.001	.009	3	1
LARGE_INTESTINE	OR10W1 →	+0.010	+3.562	<.001	.002	3	1
LARGE_INTESTINE	OR52H1 →	+0.027	+3.669	<.001	<.001	3	1
LARGE_INTESTINE	PSMB11 →	+0.024	+2.878	<.001	.009	3	1
BLOOD_Lymphoma	REG3G →	+0.033	+4.867	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

TTLL8 by ELL expression — LARGE_INTESTINE

Explore this box plot interactively →