ELK3

Across TCGA patient cohorts, ELK3 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ELK3-associated genes across cancer lineages are FASN, JNK2, and 14-3-3_beta. Each is linked with ELK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ELK3-to-partner and partner-to-ELK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by ELK3-low versus ELK3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ELK3→partner) and Y-score (partner→ELK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.316	+1.765	.032	.014	3	2
UCEC	JNK2 →	+0.218	+2.348	.003	.018	3	2
UCEC	14-3-3_beta →	-0.099	-2.295	.008	.033	3	1
UCEC	eEF2 →	+0.325	+1.415	.015	.046	3	1
UCEC	EGFR_pY1068 →	-0.195	-2.169	.038	.003	3	1
UCEC	eIF4E →	+0.188	+2.169	.017	.003	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

FASN by ELK3 expression — UCEC

Explore this box plot interactively →