ELF5

Across TCGA patient cohorts, ELF5 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ELF5-associated genes across cancer lineages are Ku80, PR, and ASNS. Each is linked with ELF5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ELF5-to-partner and partner-to-ELF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by ELF5-low versus ELF5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ELF5→partner) and Y-score (partner→ELF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.215	+1.778	.015	.008	3	2
UCEC	PR →	-0.186	-2.000	.048	.030	3	2
UCEC	ASNS →	+0.411	+2.222	.002	.010	3	2
UCEC	14-3-3_beta →	-0.110	-3.558	.003	.002	3	1
UCEC	eEF2 →	+0.355	+2.321	.008	.033	3	1
UCEC	EGFR_pY1068 →	-0.269	-2.662	.004	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Ku80 by ELF5 expression — UCEC

Explore this box plot interactively →