ELF2

Across TCGA patient cohorts, ELF2 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ELF2-associated genes across cancer lineages are Akt_pT308, PKC-delta_pS664, and beta-Catenin. Each is linked with ELF2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ELF2-to-partner and partner-to-ELF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt_pT308 grouped by ELF2-low versus ELF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ELF2→partner) and Y-score (partner→ELF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt_pT308 →	+0.557	+1.502	.016	.030	3	3
UCEC	PKC-delta_pS664 →	-0.099	-3.321	.025	.009	3	2
UCEC	beta-Catenin →	+0.432	+1.847	.020	.008	3	2
UCEC	Caspase-7-cleavedD198 →	+0.594	+2.242	.006	.005	3	2
UCEC	4E-BP1 →	+0.244	+3.169	.014	.018	3	2
UCEC	eEF2 →	+0.498	+3.807	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

Akt_pT308 by ELF2 expression — UCEC

Explore this box plot interactively →