ELF2

Across TCGA cell cohorts, ELF2 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ELF2-associated genes across cancer lineages are LIM2, OR10D3, and ITGAD. Each is linked with ELF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ELF2-to-partner and partner-to-ELF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LIM2 grouped by ELF2-low versus ELF2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ELF2→partner) and Y-score (partner→ELF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	LIM2 →	+0.017	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR10D3 →	+0.055	+4.544	.007	.003	3	1
LARGE_INTESTINE	ITGAD →	+0.014	+4.510	<.001	.001	3	1
LARGE_INTESTINE	IFIT1B →	+0.033	+3.823	.001	.006	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.012	+4.437	<.001	.004	3	1
LARGE_INTESTINE	TEX53 →	+0.105	+3.684	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

LIM2 by ELF2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →