ELF1

Across TCGA patient cohorts, ELF1 mutation is significantly associated with the RNA expression of many other genes, with 1,418 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ELF1-associated genes across cancer lineages are EXTL2P1, MKNK2P1, and MARCOL. Each is linked with ELF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ELF1-to-partner and partner-to-ELF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EXTL2P1 grouped by ELF1-low versus ELF1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ELF1→partner) and Y-score (partner→ELF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	EXTL2P1 →	+0.149	+4.536	.001	.005	3	2
HNSC	MKNK2P1 →	+0.107	+4.565	.002	.004	3	2
HNSC	MARCOL →	+1.057	+4.988	<.001	.002	3	2
LUAD	C1DP4 →	+0.134	+3.683	<.001	.003	3	2
LUAD	ATP5MFP3 →	+0.158	+4.197	<.001	.009	3	2
BRCA	TSPY18P →	+0.057	+7.057	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,418 associations by consensus.

EXTL2P1 by ELF1 expression — HNSC

Explore this box plot interactively →