Across TCGA patient cohorts, ELANE protein abundance is significantly associated with the RNA expression of many other genes, with 14,513 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ELANE-associated genes across cancer lineages are ADGRE3, FCGR3B, and CXCL1. Each is linked with ELANE in more than 9 cancer types. Because this analysis shows association rather than direction, both ELANE-to-partner and partner-to-ELANE results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ELANE→partner) and Y-score (partner→ELANE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ADGRE3 →	+0.780	+0.826	<.001	<.001	3	10
LSCC	FCGR3B →	+1.971	+0.900	<.001	<.001	3	10
UCEC	CXCL1 →	+2.221	+0.820	<.001	<.001	3	10
LUAD	CXCL8 →	+2.481	+0.942	<.001	<.001	3	10
LSCC	CEACAM3 →	+0.931	+0.989	<.001	<.001	3	10
LSCC	CXCR2 →	+1.179	+0.790	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,513 associations by consensus.

Exploration

ELANE survival (RNA) · tumor vs normal (RNA) · all ELANE data types