ELANE

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, ELANE mutation is significantly associated with the RNA expression of many other genes, with 125 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible ELANE-associated genes across cancer lineages are H3P34, OR2T5, and NPAP1P7. Each is linked with ELANE in more than 2 cancer types. Because this analysis shows association rather than direction, both ELANE-to-partner and partner-to-ELANE results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ELANE→partner) and Y-score (partner→ELANE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
SKCMH3P34 →+0.458+3.686.003.00433
LGGOR2T5 →+0.039+7.977<.001.00732
SKCMNPAP1P7 →+0.687+3.770.008.00332
COADRNA5SP322 →+0.598+6.721<.001<.00132
CESCRN7SL398P →+0.121+5.306<.001.00632
CESCOR5M14P →+0.075+5.539<.001.00432
Each partner links to its Q-omics profile. Showing the 6 strongest of 125 associations by consensus.

Exploration