Across TCGA cell cohorts, ELANE mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible ELANE-associated genes across cancer lineages are CAPZA3, OR52J3, and CARD17. Each is linked with ELANE in more than 1 cancer types. Because this analysis shows association rather than direction, both ELANE-to-partner and partner-to-ELANE results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ELANE→partner) and Y-score (partner→ELANE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CAPZA3 →	+0.210	+4.635	<.001	.003	3	1
SOFT_TISSUE	OR52J3 →	+0.019	+4.369	<.001	.008	3	1
SOFT_TISSUE	CARD17 →	+0.282	+4.977	<.001	.002	3	1
SOFT_TISSUE	TAS2R38 →	+0.026	+4.369	<.001	.008	3	1
SOFT_TISSUE	LYZL6 →	+0.014	+4.369	<.001	.008	3	1
BLOOD_Leukemia	OR7G2 →	+0.018	+5.201	.003	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

ELANE survival (RNA) · tumor vs normal (RNA) · all ELANE data types