EIF5AP3

Across TCGA pan-cancer cohorts, EIF5AP3 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of EIF5AP3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where EIF5AP3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types EIF5AP3 is over-expressed in tumor.

KIRC, COAD, and STAD are the cancer types where EIF5AP3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EIF5AP3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.300	<.001	10	view →
COAD	All	All	+0.247	<.001	8	view →
STAD	All	II,III,IV	+0.392	<.001	7	view →
BRCA	All	II,III,IV	+0.206	.001	4	view →
HNSC	Female	IV	+0.168	.002	4	view →
LIHC	All	All	+0.054	.004	4	view →
KIRP	All	III,IV	+0.322	.015	3	view →
CHOL	Female	All	+0.426	.003	2	view →
LUAD	All	All	+0.191	.013	2	view →
LUSC	All	All	+0.141	.006	2	view →
BLCA	Female	IV	+0.486	.011	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

EIF5AP3–KIRC

Open the KIRC breakdown →