EIF5AL1

Across TCGA patient cohorts, EIF5AL1 mutation is significantly associated with the RNA expression of many other genes, with 2,702 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF5AL1-associated genes across cancer lineages are ARHGAP42P4, POM121L12, and RNA5SP369. Each is linked with EIF5AL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both EIF5AL1-to-partner and partner-to-EIF5AL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARHGAP42P4 grouped by EIF5AL1-low versus EIF5AL1-high in SARC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF5AL1→partner) and Y-score (partner→EIF5AL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SARC	ARHGAP42P4 →	+0.056	+3.309	<.001	.008	3	3
BRCA	POM121L12 →	+0.026	+5.649	.002	.001	3	2
BRCA	RNA5SP369 →	+0.230	+5.281	<.001	.002	3	2
BRCA	VN1R25P →	+0.040	+4.797	.001	.005	3	2
BRCA	SFTPA3P →	+0.128	+4.857	<.001	.004	3	2
UCEC	HMGB1P28 →	+0.158	+1.324	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,702 associations by consensus.

ARHGAP42P4 by EIF5AL1 expression — SARC

Explore this box plot interactively →