EIF5AL1

Across TCGA pan-cancer cohorts, EIF5AL1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated EIF5AL1 data layer compared with 6 for mutation status.

The strongest signal is observed in small cell lung cancer (SCLC), where higher EIF5AL1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated EIF5AL1 expression acts as an unfavorable survival marker, although some lineages such as SCLC and CESC show a favorable association.

SCLC, CESC, and LUAD are the cancer types where EIF5AL1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Tertile	All	0.598	0.190	<.001	46	view →
CESC	DFS	Tertile	All	0.808	0.599	<.001	40	view →
LUAD	OS	Tertile	All	0.798	0.878	.001	38	view →
UCEC	DFS	Tertile	All	0.722	0.543	.004	28	view →
DLBC	DFS	Median	IV	1.000	0.281	.005	27	view →
BRCA	DFS	Quartile	All	0.695	0.380	.006	26	view →
LUSC	DFS	Median	II,III,IV	0.269	0.724	.001	24	view →
KIRC	OS	Median	All	0.588	0.716	.004	18	view →
UVM	OS	Quartile	All	0.787	0.969	.014	10	view →
LAML	DFS	Quartile	All	0.374	0.711	.025	10	view →
SKCM	OS	Quartile	II,III,IV	0.193	0.428	.004	9	view →
ESCA	DFS	Quartile	All	0.370	0.573	.033	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

EIF5AL1–SCLC (OS)

Open the SCLC breakdown →