EIF5AL1

Across TCGA patient cohorts, EIF5AL1 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF5AL1-associated genes across cancer lineages are MEK1, ATM, and ERK2. Each is linked with EIF5AL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both EIF5AL1-to-partner and partner-to-EIF5AL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by EIF5AL1-low versus EIF5AL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF5AL1→partner) and Y-score (partner→EIF5AL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.493	+3.906	<.001	<.001	3	3
UCEC	ATM →	-0.778	-2.201	<.001	<.001	3	3
UCEC	ERK2 →	+0.265	+2.999	<.001	<.001	3	2
UCEC	GSK3-a-b →	+0.091	+2.000	.043	.029	3	2
UCEC	INPP4B →	-0.374	-2.502	<.001	.001	3	2
UCEC	PDCD4 →	-0.542	-1.321	<.001	.029	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

MEK1 by EIF5AL1 expression — UCEC

Explore this box plot interactively →