EIF5A2

Across TCGA pan-cancer cohorts, EIF5A2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated EIF5A2 data layer compared with 21 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher EIF5A2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated EIF5A2 expression acts as an unfavorable survival marker.

LSCC, CCRCC, and LUAD are the cancer types where EIF5A2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	All	0.832	0.963	.008	29	view →
CCRCC	OS	Median	III,IV	0.133	0.989	.013	9	view →
LUAD	OS	Median	II,III,IV	0.405	0.861	.005	8	view →
GBM	OS	Quartile	All	0.699	0.995	.034	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

EIF5A2–LSCC (OS)

Open the LSCC breakdown →