EIF5A2

Across TCGA pan-cancer cohorts, EIF5A2 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of EIF5A2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where EIF5A2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types EIF5A2 is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

HNSC, COAD, and THCA are the cancer types where EIF5A2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EIF5A2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+2.153	<.001	12	view →
COAD	Female	II,III,IV	+1.147	<.001	11	view →
THCA	Male	III,IV	−0.998	<.001	9	view →
LIHC	Female	II,III,IV	+1.173	<.001	7	view →
LUSC	Male	All	+1.399	<.001	6	view →
LUAD	All	All	+0.408	<.001	6	view →
CHOL	All	All	+1.682	.001	4	view →
READ	Male	All	+1.303	.031	3	view →
UCEC	All	All	−0.585	.021	2	view →
PRAD	All	All	−0.335	.007	2	view →
BRCA	All	All	−0.187	.021	2	view →
BLCA	Male	IV	−1.019	.004	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

EIF5A2–HNSC

Open the HNSC breakdown →