EIF5A2

Across TCGA patient cohorts, EIF5A2 mutation is significantly associated with the RNA expression of many other genes, with 3,357 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF5A2-associated genes across cancer lineages are ADM, LIN7C, and IMMP1L. Each is linked with EIF5A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF5A2-to-partner and partner-to-EIF5A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADM grouped by EIF5A2-low versus EIF5A2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF5A2→partner) and Y-score (partner→EIF5A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ADM →	+0.661	+1.389	.007	.005	3	1
UCEC	LIN7C →	+0.450	+1.660	.001	.003	3	1
UCEC	IMMP1L →	+0.310	+1.595	.003	.001	3	1
UCEC	HSD17B12 →	+0.437	+1.787	.001	.007	3	1
UCEC	SSRP1 →	+0.459	+3.054	<.001	<.001	3	1
UCEC	PTPRJ →	+0.481	+2.523	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,357 associations by consensus.

ADM by EIF5A2 expression — UCEC

Explore this box plot interactively →