EIF5A2

Across TCGA patient cohorts, EIF5A2 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF5A2-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and A-Raf_pS299. Each is linked with EIF5A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF5A2-to-partner and partner-to-EIF5A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by EIF5A2-low versus EIF5A2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF5A2→partner) and Y-score (partner→EIF5A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.278	-2.584	<.001	<.001	3	1
UCEC	eIF4E →	+0.242	+3.713	<.001	<.001	3	1
UCEC	A-Raf_pS299 →	-0.146	-2.169	<.001	.003	3	1
UCEC	FASN →	+0.456	+2.643	<.001	<.001	3	1
UCEC	FOXO3a_pS318_S321 →	-0.126	-1.797	.002	.003	3	1
UCEC	GATA6 →	-0.109	-1.314	.035	.029	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

EGFR_pY1068 by EIF5A2 expression — UCEC

Explore this box plot interactively →