EIF4H

Across TCGA pan-cancer cohorts, EIF4H mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated EIF4H data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher EIF4H mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated EIF4H expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

UCEC, CCRCC, and LSCC are the cancer types where EIF4H mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.944	0.482	.004	20	view →
CCRCC	DFS	Median	All	0.616	0.834	.005	19	view →
LSCC	OS	Median	II,III,IV	0.892	0.580	.004	12	view →
PDAC	DFS	Median	IV	0.250	0.934	.024	6	view →
LUAD	DFS	Median	III,IV	0.886	0.595	.014	5	view →
HNSC	OS	Median	All	0.993	0.941	.028	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

EIF4H–UCEC (DFS)

Open the UCEC breakdown →