EIF4H

Across TCGA pan-cancer cohorts, EIF4H RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of EIF4H’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where EIF4H RNA is more highly expressed in tumor relative to normal tissue. In most cancer types EIF4H is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

HNSC, KIRC, and THCA are the cancer types where EIF4H tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EIF4H RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.661	<.001	11	view →
KIRC	Female	All	+0.495	<.001	11	view →
THCA	All	All	−0.317	<.001	9	view →
LIHC	Female	All	+0.627	<.001	7	view →
CHOL	All	All	+1.318	<.001	5	view →
LUSC	Male	II,III,IV	+0.543	<.001	5	view →
KIRP	All	IV	+0.775	.013	4	view →
LUAD	All	II,III,IV	+0.240	.032	3	view →
UCEC	All	All	−0.587	.013	2	view →
ESCA	All	All	+0.546	.031	1	view →
KICH	Female	All	−0.400	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

EIF4H–HNSC

Open the HNSC breakdown →