EIF4H

Across TCGA patient cohorts, EIF4H mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF4H-associated genes across cancer lineages are JNK_pT183_Y185, Notch1, and EGFR_pY1068. Each is linked with EIF4H in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF4H-to-partner and partner-to-EIF4H results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by EIF4H-low versus EIF4H-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF4H→partner) and Y-score (partner→EIF4H) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.196	-2.459	.006	.019	3	2
UCEC	Notch1 →	+0.185	+3.179	.001	.010	3	2
UCEC	EGFR_pY1068 →	-0.268	-4.000	.011	<.001	3	1
UCEC	eIF4G →	+0.267	+2.999	.042	.035	3	1
UCEC	FoxM1 →	+0.280	+2.222	.010	.011	3	1
UCEC	JNK2 →	+0.319	+3.594	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

JNK_pT183_Y185 by EIF4H expression — UCEC

Explore this box plot interactively →