EIF4BP8

Across TCGA pan-cancer cohorts, EIF4BP8 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of EIF4BP8’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where EIF4BP8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types EIF4BP8 is over-expressed in tumor, although a few such as BRCA and THCA show the opposite, repressed pattern.

HNSC, COAD, and BRCA are the cancer types where EIF4BP8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EIF4BP8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.092	<.001	12	view →
COAD	All	II,III,IV	+0.114	.002	6	view →
BRCA	Female	All	−0.021	.007	6	view →
LUSC	Male	All	+0.041	.012	3	view →
LUAD	All	All	+0.053	.001	2	view →
PRAD	All	All	+0.053	.004	2	view →
KICH	All	III,IV	+0.052	.021	2	view →
KIRC	Male	All	+0.029	.012	2	view →
THCA	All	All	−0.027	.026	2	view →
LIHC	All	II,III,IV	+0.020	.046	2	view →
BLCA	Female	IV	−0.056	.013	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

EIF4BP8–HNSC

Open the HNSC breakdown →