EIF4A3

Across TCGA patient cohorts, EIF4A3 mutation is significantly associated with the RNA expression of many other genes, with 584 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF4A3-associated genes across cancer lineages are H3Y1, DUTP3, and ETF1P3. Each is linked with EIF4A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF4A3-to-partner and partner-to-EIF4A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H3Y1 grouped by EIF4A3-low versus EIF4A3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF4A3→partner) and Y-score (partner→EIF4A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	H3Y1 →	+0.576	+2.000	.009	.006	3	2
SKCM	DUTP3 →	+0.245	+5.408	<.001	.002	3	2
UCEC	ETF1P3 →	+0.174	+2.205	<.001	.002	3	2
BRCA	WBP1LP8 →	+0.079	+7.473	<.001	.007	3	1
BRCA	MIR6780A →	+0.666	+4.766	<.001	.003	3	1
SKCM	OR1B1 →	+0.034	+5.039	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 584 associations by consensus.

H3Y1 by EIF4A3 expression — UCEC

Explore this box plot interactively →