Across TCGA pan-cancer cohorts, EIF4A2P4 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of EIF4A2P4’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where EIF4A2P4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types EIF4A2P4 is over-expressed in tumor, although a few such as UCEC and BRCA show the opposite, repressed pattern.
COAD, UCEC, and BRCA are the cancer types where EIF4A2P4 tumor–normal differential expression is most reproducible.