EIF4A2

Across TCGA patient cohorts, EIF4A2 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF4A2-associated genes across cancer lineages are Cyclin-E2, eEF2, and Chk2_pT68. Each is linked with EIF4A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF4A2-to-partner and partner-to-EIF4A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by EIF4A2-low versus EIF4A2-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF4A2→partner) and Y-score (partner→EIF4A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	Cyclin-E2 →	+0.212	+3.459	.010	.005	3	2
UCEC	eEF2 →	+0.257	+1.362	.042	.037	3	2
UCEC	Chk2_pT68 →	-0.139	-2.295	.034	.033	3	2
BLCA	ETS-1 →	-0.178	-2.287	.048	.035	3	1
UCEC	14-3-3_beta →	-0.094	-2.432	.007	.018	3	1
UCEC	EGFR_pY1068 →	-0.196	-2.000	.027	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Cyclin-E2 by EIF4A2 expression — BLCA

Explore this box plot interactively →