EIF4A2

Across TCGA pan-cancer cohorts, EIF4A2 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated EIF4A2 data layer compared with 5 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher EIF4A2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated EIF4A2 expression acts as an unfavorable survival marker, although some lineages such as UVM and LUSC show a favorable association.

SCLC, UVM, and ACC are the cancer types where EIF4A2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Median	All	0.427	0.705	<.001	77	view →
UVM	DFS	Quartile	All	0.933	0.426	<.001	53	view →
ACC	DFS	Tertile	All	0.236	0.701	<.001	42	view →
LUSC	OS	Quartile	All	0.766	0.578	<.001	39	view →
LGG	OS	Median	All	0.931	0.856	<.001	32	view →
KIRP	DFS	Median	All	0.788	0.919	.001	30	view →
LIHC	DFS	Quartile	All	0.420	0.613	<.001	25	view →
SKCM	DFS	Median	All	0.786	0.658	.001	19	view →
KICH	DFS	Median	All	0.781	1.000	.002	18	view →
ESCA	OS	Tertile	IV	0.143	0.713	.024	18	view →
UCEC	DFS	Median	All	0.547	0.745	.001	16	view →
CHOL	DFS	Tertile	II,III,IV	0.608	0.103	.004	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

EIF4A2–SCLC (OS)

Open the SCLC breakdown →