EIF4A2

Across TCGA cell cohorts, EIF4A2 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible EIF4A2-associated genes across cancer lineages are OR52K1, OR12D3, and PNLIPRP1. Each is linked with EIF4A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF4A2-to-partner and partner-to-EIF4A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR52K1 grouped by EIF4A2-low versus EIF4A2-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF4A2→partner) and Y-score (partner→EIF4A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	OR52K1 →	+0.030	+3.432	<.001	.008	3	2
OVARY	OR12D3 →	+0.012	+4.807	<.001	.003	3	1
OVARY	PNLIPRP1 →	+0.031	+4.450	<.001	.004	3	1
OVARY	SCT →	+0.149	+4.029	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

OR52K1 by EIF4A2 expression — STOMACH

Explore this box plot interactively →