EIF4A1

Across TCGA patient cohorts, EIF4A1 mutation is significantly associated with the RNA expression of many other genes, with 1,669 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF4A1-associated genes across cancer lineages are RNU6-752P, LRRC6P1, and RPL31P9. Each is linked with EIF4A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both EIF4A1-to-partner and partner-to-EIF4A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-752P grouped by EIF4A1-low versus EIF4A1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF4A1→partner) and Y-score (partner→EIF4A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU6-752P →	+0.171	+5.000	<.001	.001	3	3
CESC	LRRC6P1 →	+0.019	+4.252	<.001	.006	3	3
CESC	RPL31P9 →	+0.166	+5.100	<.001	<.001	3	3
UCEC	DPY19L4P2 →	+0.079	+1.561	.001	.007	3	3
BRCA	SNORA1B →	+0.413	+5.148	.008	.008	3	2
LUAD	H2ACP2 →	+0.417	+5.217	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,669 associations by consensus.

RNU6-752P by EIF4A1 expression — CESC

Explore this box plot interactively →